Cellular mechanism of AgNP toxicity


The project has been divided into three section: (a) Biological evaluation of AgNP toxicity, (b) Biochemical and Physiological evaluation and (c) Evalutaion of gene expressiojn changes associated with AgNP toxicity. Our first two aims are now complete. Due to limitation of space we are unable to produce all the data in this report, but to summarize our findings establish that (a) exposure to AgNP at sublethal concentration cause cuticular
demelanization, shortening of life span and reduced female fertility, (b) Biochemical data pointed out that the activity of tyrosinase and Cu-Zn SOD dismutase are both reduced in high AgNp enviroment. With the help of AA analysis we now confirm that a significant amount of Ag is accumulated in these animals.